Saturday, October 13, 2012

Shot fired at Obama campaign office in Denver

Rachel Maddow talks with Denver police spokesperson Raquel Lopez about the details known so far about a gun shot fired at the Obama campaign headquarters in Denver, Colorado.

By NBC News staff

Denver police were looking for a person who shot at a campaign office for President Barack Obama on Friday, NBC station KUSA reported.?

Police say there were people inside the office at the time of the 3 p.m. shooting, but no one was hit.

A single bullet struck the office and broke the window, Detective Raquel Lopez, Denver police spokesperson, told NBC News. But detectives could not confirm that the shot was fired with the intent to hit the office.

Detectives were still investigating the intent of the shot. They were looking into the possibility the shot was fired from a vehicle.

Read more at 9news.com, KUSA's website

Police were reviewing surveillance video for possible leads, KUSA reported. Investigators said they have a "vehicle of interest" and are interviewing witnesses.

A campaign official confirmed the incident but referred questions to the Denver police.

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Source: http://usnews.nbcnews.com/_news/2012/10/12/14402669-shot-fired-at-obama-campaign-office-in-denver?lite

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Yes On Idaho's Innovative Educational Reform Measures - - Idaho ...

By Richard Larsen

There are three Propositions on the general election ballot in Idaho. If all three receive a majority vote, the Students Come First legislation signed into law last year, will remain on the books and will begin the process of innovatively ameliorating the quality of public education across the state.

Proposition 1 does primarily three things. It allows for parents to have input on teacher evaluations, phases out tenure for educators, and mandates that contract negotiations be conducted in open meetings.

A supportive and involved parent largely determines the academic success of a student. Including parental involvement in teacher evaluations will foster a more synergistic relationship between the teacher and the parent, with the predictable outcome of additional parental involvement and children who perform better academically.

Teacher tenure is preserved for those who already have it. Tenure is an obstacle for school districts and administrators to work around when faced with reductions in force. Phasing out tenure allows increased flexibility to retain the best teachers, regardless of seniority or tenure. This is clearly in the best interest of students and academic performance, but is also the major objection teachers have to the Students Come First legislation.

Collective bargaining is limited to matters pertaining to salary and benefits. In the past they could negotiate bell schedule, school calendar, teacher evaluations, and grading methods. This gives the local school board more flexibility and latitude in those peripheral issues without jeopardizing salary and benefit negotiations.

Contract negotiations have sailed through with few exceptions, since the open-meeting negotiations law went into effect. Everyone involved in such negotiations behaves more circumspectly when the public eye is on them.

Proposition 2 implements Pay for Performance (PFP) incentives for teachers, allowing for bonuses based on one of three criteria. The minimum teacher salary was raised and a funding mechanism added to increase the minimum salary in the future. The current salary apportionment grid for teachers with longevity and added educational credits is maintained.

PFP provides extra compensation for teachers who serve in hard-to-fill positions, like calculus teachers in small school districts, or leadership roles, like mentoring new teachers or developing curriculum. This comes as a bonus to those teachers on top of their pay grid compensation. The local school board determines hard-to-fill positions and the extra compensation.

PFP also allows for teachers to earn bonuses beyond their base salary for meeting or exceeding student achievement goals at the state and local levels. This will provide for the entire certified staff of a school to receive bonus pay when their school is showing growth in student achievement. Local school boards set student achievement goals for bonus participation. Bonuses will be paid to nearly 85% of Idaho?s teachers next month, based on last year?s performance.

Proposition 3 allows for high school juniors and seniors to earn up to a years worth of college credit, and provides for technology in the classroom as well as individually to students. In addition, new standards of transparency and public disclosure are required of school districts.

All local school boards and school districts must be totally transparent in fiscal matters, including master contracts and associated information. Further, the State Department of Education will create a web-based fiscal report card and will post financial data and statistics for every school district and public charter school.

For teachers who don?t already have a personal computer in their classroom, they will get one. They will also be trained on how to integrate computer technology into the curriculum and into the classroom to raise student achievement. This school year, high school teachers will be provided mobile computing devices.

High school students will be provided access to similar devices. Local districts will determine how best to utilize this technology on a daily basis and teachers will decide how to incorporate them into the learning process. The local boards will also set student-use policy for the mobile devices.

Starting with the graduating class of 2016, students will have some online curriculum. The State Board of Education has determined that two of the 46 credits required to graduate will be completed online, but local districts will determine the curriculum. And the digital learning component allows students in small districts to enjoy the same curriculum breadth of the larger schools.

As taxpayers, we benefit by the increased transparency in the disposition of financial resources. As parents of public schools, we benefit by the increased focus on results and achievement, by rewarding schools and teachers for jobs well done. The incorporation of technology in the classroom and online curriculum prepares students for college and the work force, while increasing efficiency. And the Students Come First legislation empowers teachers to earn more based on their performance and grants more flexibility and authority to local school boards to manage resources. Everyone should visit the studentscomefirst.org website to learn more.

There is no doubt that each of these measures brings something to the table to improve our public education system. All three Propositions should be approved to realize those benefits.

AP award winning columnist Richard Larsen is President of Larsen Financial, a brokerage and financial planning firm in Pocatello, and is a graduate of Idaho State University with a BA in Political Science and History and former member of the Idaho State Journal Editorial Board.? He can be reached at rlarsenen@cableone.net.?

Source: http://www.pocatelloshops.com/new_blogs/politics/?p=9675

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Friday, October 12, 2012

Engineered flies spill secret of seizures

ScienceDaily (Oct. 11, 2012) ? Scientists have observed the neurological mechanism behind temperature-dependent -- febrile -- seizures by genetically engineering fruit flies to harbor a mutation analogous to one that causes epileptic seizures in people. In addition to contributing the insight on epilepsy, their new study also highlights the first use of genetic engineering to swap a human genetic disease mutation into a directly analogous gene in a fly.

In a newly reported set of experiments that show the value of a particularly precise but difficult genetic engineering technique, researchers at Brown University and the University of California-Irvine have created a Drosophila fruit fly model of epilepsy to discern the mechanism by which temperature-dependent seizures happen.

The researchers used a technique called homologous recombination -- a more precise and sophisticated technique than transgenic gene engineering -- to give flies a disease-causing mutation that is a direct analogue of the mutation that leads to febrile epileptic seizures in humans. They observed the temperature-dependent seizures in whole flies and also observed the process in their brains. What they discovered is that the mutation leads to a breakdown in the ability of certain cells that normally inhibit brain overactivity to properly regulate their electrochemical behavior.

In addition to providing insight into the neurology of febrile seizures, said Robert Reenan, professor of biology at Brown and a co-corresponding author of the paper in the Journal of Neuroscience, the study establishes

"This is the first time anyone has introduced a human disease-causing mutation overtly into the same gene that flies possess," Reenan said.

Engineering seizures

Homologous recombination (HR) starts with the transgenic technique of harnessing a transposable element (jumping gene) to insert a specially mutated gene just anywhere into the fly's DNA, but then goes beyond that to ultimately place the mutated gene into exactly the same position as the natural gene on the X chromosome. HR does this by outfitting the gene to be handled by the cell's own DNA repair mechanisms, essentially tricking the cell into putting the mutant copy into exactly the right place. Reenan's success with the technique allowed him to win a special grant from the National Institutes of Health last year.

The new paper is a result of that grant and Reenan's collaboration with neurobiologist Diane O'Dowd at UC-Irvine. Reenan and undergraduate Jeff Gilligan used HR to insert a mutated version of the para gene in fruit flies that is a direct parallel of the mutation in the human gene SCN1A that causes febrile seizures in people.

When the researchers placed flies in tubes and bathed the tubes in 104-degree F water, the mutant fruit flies had seizures after 20 seconds in which their legs would begin twitching followed by wing flapping, abdominal curling, and an inability to remain standing. After that, they remained motionless for as long as half an hour before recovering. Unaltered flies, meanwhile, exhibited no temperature-dependent seizures.

The researchers also found that seizure susceptibility was dose-dependent. Female flies with mutant strains of both copies of the para gene (females have two copies of the X chromosome) were the most susceptible to seizures. Those in whom only one copy of the gene was a mutant were less likely than those with two to seize, but more likely than the controls.

While the researchers at Brown compared the seizure susceptibility of whole flies, O'Dowd, lead author Lei Sun, and colleagues at Irvine studied individual fly neurons implicated in seizure activity to see how they behaved as the brains were heated. What their measurements revealed in the mutant flies were flaws in how "GABAergic" neurons take in sodium through channels in the cell membrane. Under normal circumstances, the neurons inhibit brain overactivity. But the mutants' mishandling of sodium led them to fail electrically.

"When [O'Dowd's team] isolates those currents due to the sodium channel, which is what's mutated in this case, and she compares the normal animals to the disease-model animals, what happens is the mutant channels pass too much current," Reenan said. "The channels open too easily and they take more effort to close. They open too soon and they close too late. That effect is magnified at higher temperature. Then the neuron can't send any [inhibitory] signals."

Searching for therapies

With a useful genetic model of epilepsy in fruit flies, Reenan said he is optimistic that researchers can now look for potential treatments for the disease. The next step, he said, is to use the practice of "forward genetics" to look for further mutations that might counter febrile seizures.

Given thousands of flies with model of the disease, scientists can purposely subject them to different DNA-altering conditions and then look to see if any flies lose their propensity for seizures. Among those that do, the researchers can then identify the specific genetic alteration responsible and determine whether that could ever be clinically applied. For example, if it turns out that a mutation proves therapeutic because it causes a certain protein to be overexpressed, then perhaps that protein could be refined into some kind of biologic pharmaceutical.

Reenan said he'd expect to see researchers follow a similar roadmap for other diseases as well.

"Knock-in of specific disease-causing mutations into the fly genome has the potential to provide a rapid and low-cost platform for studying the cellular mechanisms of heritable human diseases," the authors wrote. "In addition, knock-in flies can be used in combination with forward genetic screens to identify suppressor and/or enhancer mutations, a strategy that is challenging in humans and rodent models but well established in Drosophila."

In addition to Reenan, Gilligan, O'Dowd and Sun, other authors are Cynthia Staber of Brown and Ryan Schutte and Vivian Nguyen of UC Irvine.

In addition to the National Institutes of Health, the Howard Hughes Medical Institue and the Ellison Medical Foundation funded the research.

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The above story is reprinted from materials provided by Brown University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. L. Sun, J. Gilligan, C. Staber, R. J. Schutte, V. Nguyen, D. K. O'Dowd, R. Reenan. A Knock-In Model of Human Epilepsy in Drosophila Reveals a Novel Cellular Mechanism Associated with Heat-Induced Seizure. Journal of Neuroscience, 2012; 32 (41): 14145 DOI: 10.1523/JNEUROSCI.2932-12.2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/UMGo0WkKb3w/121011151623.htm

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Video: Fantasy football: Buy low, sell high on these guys

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Source: http://nbcsports.msnbc.com/id/21134540/vp/49367310#49367310

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Small businesses can start on a shoestring but increase in value ...

The Canadian Press - ONLINE EDITION

MONTREAL - The majority of Canada's small business owners started out with less than $5,000 to get up and running, suggests a survey on entrepreneurship.

Intuit Canada said Friday its research found that 58 per cent of small business owners surveyed started out with less than $5,000 and 79 per cent started their business with less than $20,000.

"Canada is a nation of small businesses," said Barb Anderson, global product leader at Intuit, an accounting software company for small and mid-sized businesses.

Anderson said 98 per cent of businesses in Canada are small- or medium-sized.

The survey included business owners that had 20 employees or less and were service and product businesses.

Intuit Canada also said 19 per cent of those surveyed took out a loan or line of credit and 18 per cent drained their savings account when they started their businesses.

The first year of business can be a "really tumultuous time" and business owners have to get a handle on money coming in and money going out, she said.

About 85 per cent of new businesses survive one year and that drops to 70 per cent in the second year, Anderson said from Mississauga, Ont.

"One of the key reasons we know that businesses don't survive is due to poor financial management."

Intuit Canada said data from Statistics Canada shows that small businesses with fewer than 100 employees created 20,000 jobs in the last year and 48 per cent of the total private sector labour force is employed by small businesses.

"There's so many potential businesses out there and they have a dream and they have an idea and this really demonstrates to them that you can get it done with just small, small investments,"Anderson said.

The Canadian Federation of Independent Business said many small business owners have started their business at their kitchen table.

"Tons and tons of small businesses are started on a shoestring," said federation chief executive Dan Kelly.

Kelly said small business owners go into business because they're good at something, like plumbing or cooking, but not necessarily good at managing money and should seek help.

"You're not automatically some financial guru just because you've started a firm. That's where many firms go wrong and there is a huge failure rate of many small businesses that go in with the best of intentions."

Meanwhile, a separate study by the Bank of Montreal (TSX:BMO) found six in 10 small business owners polled have seen the value of their business grow by an average of 39 per cent over the last five years.

The BMO study also found that 23 per cent of entrepreneurs surveyed valued the legacy it creates for their family and the income it generates.

"Canadian businesses are continually increasing in value: not only in an everyday, tangible sense, but in what the business brings to the entire family," said Steve Murphy, senior vice-president of commercial banking at BMO.

"With many Canadian business owners on the cusp of retirement and their businesses thriving, creating a succession plan should be a priority to ensure their hard-earned success continues in the way they envision it," Murphy said.

A BMO study conducted earlier this year found that 58 per cent of Canada's small business owners didn't have a succession plan in place.

The BMO survey was conducted by Pollara between Aug. 13 and Sept. 5 with 500 Canadian business owners. Results are considered accurate plus or minus 4.4 per cent, 19 times out of 20.

The Intuit Canada study was done online by Angus Reid Public Opinion between Aug. 16 and Aug. 21. Results are considered accurate plus or minus 4.4 per cent, 19 times out of 20.

The release of the surveys comes ahead of Monday's kick-off of Canadian small business week.

Source: http://www.winnipegfreepress.com/business/finance/small-businesses-increase-in-value-many-start-with-less-than-5000-studies-173898571.html

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Thursday, October 11, 2012

BlackRock's boy wonder - The Term Sheet: Fortune's deals blog ...

By Mina Kimes

FORTUNE -- Toward the end of a BlackRock earnings call in July, an analyst asked Larry Fink, the CEO of the asset management giant, about his bench of successors. Fink named a few well-known executives?the president, the chief operating officer. Then he mentioned a less familiar name. "You are going to hear more and more, as investors, about Rob Goldstein," he told the analyst, referring to the head of BlackRock Solutions, the firm's analytics and advisory division. ? Fink meant what he said. Two weeks later he announced that he was installing Goldstein on the firm's executive committee and also putting him in charge of BlackRock's entire institutional business, which represents $2.2 trillion in long term assets. In addition to his new role, Goldstein will continue to run BlackRock Solutions. "He's a very pragmatic type of guy who is able to do problem solving in a very straightforward way," Fink tells Fortune.

At just 38 years old, Rob Goldstein has risen to the upper echelons of the world's biggest money manager. But he maintains a low profile, drawing less attention than most young stars on Wall Street. The same could be said about BlackRock Solutions, the little known, influential division Goldstein helped create and has run since 2009. The secretive 900-person unit is like a consulting firm inside BlackRock, offering expensive technological services and advice to banks, pension funds, and governments around the world. Its $510 million in revenue is a drop in the proverbial bucket of the $9.1 billion that BlackRock generated last year. But as the money manager increasingly seeks to position itself as a holistic problem solver, BlackRock Solutions' role in the company?and Goldstein himself--will accrue greater significance to the firm.

Goldstein, who just moved into a new window office (the most prominent decorations are drawings by his two young children), is a classic BlackRock guy: nerdy, quirky, and quietly ambitious. The executive gets visibly excited when he talks about sorting through vast amounts of data. He is both a self-described gadget geek and a massive Deadhead. Dressed in shirtsleeves, cufflinks engraved with fraction signs, and a tie dotted with tiny Zodiac symbols, Goldstein admits that he regularly reads his horoscope (his sign, Sagittarius?energetic and adventurous?describes him, he says). He waits until the evening to read it so he can see how the prediction panned out. "There must be a database of responses and some algorithm that does it," he muses.

MORE: Fortune's 40 Under 40

Born and raised in Canarsie?with the accent to prove it--Goldstein was a math whiz growing up; he skipped eighth grade and graduated from high school at the age of 16. His father, a teacher who later became a broker, told him that he could have a car (a used Acura Integra) if he went to SUNY Binghamton instead of an expensive private college. Goldstein agreed to the deal, even though he wasn't old enough to drive until his second semester of school.

After studying economics at college, Goldstein knew he was interested in finance, but the big banks didn't recruit at Binghamton, so he wrote letters to several companies. He received numerous rejections, but he got a "yes" from BlackRock, then a 55-person firm occupying half a floor in a Park Avenue office building. When Goldstein came on board in 1994, he recalls, there were only six people in that year's intake of analysts.

BlackRock, which Fink founded in 1988 with former First Boston colleagues as an asset management division of private equity giant Blackstone, has always stressed risk management. In its early days the company regularly churned out risk reports on all of its portfolios--an unusual practice for a buy-side firm, recalls Goldstein, who used to compare the daily reports by hand to search for inconsistencies, using a ruler to keep his place. The analysts delivered these summaries, which were printed on green paper, to BlackRock's portfolio managers. Soon BlackRock's customers started to ask for their own daily risk reports, and in 1994 the company started selling a service called "The Green Package" to clients.

The company's next big analytics product, Aladdin, was hatched in a similar fashion. BlackRock created an internal operating system to manage and analyze its investment portfolios. In the late '90s, one of BlackRock's clients asked the firm if it could come install the same technology at its offices. The client named the platform Aladdin, which stands for Asset Liability and Debt and Derivative Investment Network. Goldstein and his associates finished the complex task of integrating Aladdin into the client's systems in 2000, marking the official launch of BlackRock Solutions. Today Aladdin has 50 customers--enormous money managers like sovereign wealth funds and banks--who pony up recurring fees for the product and generate about two thirds of the division's annual revenue.

MORE: 40 Under 40 photo portfolio

Goldstein, who didn't even have a passport until 2004, now travels regularly around the world. He has a desk drawer full of ID badges from different clients. He won't show them to anyone. "I never say client names," he says, slamming the drawer shut. That discretion proved essential during the financial crisis, when BlackRock Solutions became the de-facto consigliere for the world's biggest financial institutions and governments. Around 2007, Goldstein says, the firm realized it could leverage its analytics power to help other firms evaluate their complex mortgage products. So Goldstein put together a special-ops style team of 200 consultants equipped to tackle tricky financial problems. Though Goldstein refuses to disclose details, some of the unit's high profile assignments have come to light. The U.S. government hired the firm to manage the mortgage securities it purchased from troubled insurer AIG in 2008; Ireland enlisted BlackRock Solutions to help it evaluate its banking system. More recently, the firm was commissioned by Greece to assess the financial health of its local banks.

In 2009, Fink officially named Goldsein head of BlackRock Solutions. The division's value to the firm transcends its contribution to the overall bottom line. For one, BlackRock Solutions' ties to financial giants and governments have burnished the entire company's reputation. (It has also caused some to worry that BlackRock's investment managers could leverage inside information; the firm maintains that it has rigid firewalls in place.) Robert Lee, an analyst at Keefe, Bruyette, and Woods, says BlackRock Solutions, with its focus on analytics and risk management, is the "backbone" of the company. "Its relative importance in the organization is greater than its revenue contribution," he says. "To understand BlackRock, it helps to understand BlackRock Solutions."

It is also a hothouse for innovation. For example, Goldstein's team recently tested a new product that will enable existing Aladdin clients and BlackRock portfolio managers to trade bonds electronically, circumventing brokers at big banks. The Aladdin Trading Network, rumored to be on the drawing table for a few years now, will be up and running in early 2013, says Goldstein. There is a greater urgency, he says, because of the liquidity crunch in fixed income trading. Banks have drastically cut back on the number of bonds they hold in their coffers, partly in response to new regulations, making it harder for investors to buy the assets they need at reasonable prices. Goldstein points out that electronic trading in stocks is the status quo; it's only a matter of time before the same thing happens for bonds, which are still traded by phone most of the time. "Sometimes the great innovations are just doing the obvious--but having the wherewithal to execute," he says.

Some investors are dubious about whether Aladdin Trading Network--and the various other fixed income trading systems springing up at banks and technology firms--will work. When investors trade bonds, they are often haggling over highly specific securities; it's generally more difficult to trade a thousand bonds with unique attributes than it is to trade one thousand shares of common stock. But Aladdin's clients have more than $12 trillion in assets, which should make it easier for BlackRock to facilitate matches.

As head of BlackRock's institutional business, Goldstein now has the wherewithal to pitch BlackRock Solutions' services to a wider berth of clients. His elevation signifies a strategic evolution at BlackRock. As investors shift their money into low-cost ETFs and index funds, the asset management industry faces the prospect of shrinking margins. BlackRock, meanwhile, is looking to become more than just a money manager--the firm wants to be seen as an advisor, analytics provider, and all around problem solver.

Goldstein's career path?he started at BlackRock at the age of twenty and never left?makes him an anomaly in the high-turnover finance industry. He says that's by design. "My personal opinion is that moving around a lot, particularly in a world where things are getting more and more complicated, is not a good career strategy." "Every time you move, you're resetting a knowledge curve." While he says his core responsibility, problem solving, hasn't changed much over the years, new challenges have kept his job interesting. "The good news," he adds, "is today there's a surplus of hard problems."

Source: http://finance.fortune.cnn.com/2012/10/11/rob-goldstein-blackrock/

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Magic Johnson Reveals How HIV Brought His Family Closer

While HIV is no longer an automatic death sentence for its carriers, it’s still a chronic and serious health concern for most. However, for Magic Johnson, who announced his HIV-positive status in 1991, the disease had one positive side effect. 

Source: http://www.ivillage.com/magic-johnson-reveals-how-hiv-brought-his-family-closer/1-a-493386?dst=iv%3AiVillage%3Amagic-johnson-reveals-how-hiv-brought-his-family-closer-493386

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